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검색으로 10,000+ 프로그램 중 최대 5개를 골라 PK/PD · 독성 · 임상을 나란히 비교합니다. · 다음 갱신 D-13 · 마지막 7월 13일

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항목
AntibodyPhase 1
Adjuvant chemoradiotherapy (Adjuvant chemoradiotherapy)
University of Manitoba·Esophageal Cancer
ORR 40%
Overview
Program
Adjuvant chemoradiotherapy
Overview
Company
University of Manitoba
Overview
Modality
ANTIBODY
Overview
Target
Esophageal Cancer
Overview
Indication
Esophageal Cancer
Overview
Phase
PHASE_1
Overview
Status
RECRUITING
MoA
Mechanism
target epithelial-mesenchymal transition through the Wnt/β-catenin/TCF7 signaling pathway
MoA
Biomarker
PD-L1 expression
PK/PD
Species
Mouse, Human
PK/PD
Animal (cat.)
Human, Mouse
PK/PD
Experiment
PD
Toxicology
Species
Mouse, Human
Toxicology
Animal (cat.)
Human, Mouse
Toxicology
Major finding
Adjuvant chemoradiotherapy versus completion total mesorectal excision after local excision for early rectal cancer (TESAR): a multicentre, randomised, controlled, phase 3, non-inferiority trial.. Completion total mesorectal excision (cTME) after local excision of early rectal cancer is associated with substantial morbidity and impaired functional outcomes. This study aimed to assess the oncologic…
Clinical
Primary efficacy
ORR 40%
Clinical
ORR
40%
Clinical
OS
20.27
Clinical
Result source
ClinicalTrials.gov NCT01390948
Clinical
Data Tier / Score
A · 46
Clinical
Program phase
PHASE_1
Clinical
Clinical sync
2026년 7월 13일 (1일 전)