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항목
AntibodyPhase 2
BA3021 (BA3021)
Canadian Cancer Trials Group·Ovarian Cancer
3 trials
Overview
Program
BA3021
Overview
Company
Canadian Cancer Trials Group
Overview
Modality
ANTIBODY
Overview
Target
Ovarian Cancer
Overview
Indication
Ovarian Cancer
Overview
Phase
PHASE_2
Overview
Status
RECRUITING
MoA
Biomarker
biomarker review, neither sub-study proceeded to second stage accrual
PK/PD
Species
NHP, Mouse, Human
PK/PD
Animal (cat.)
Human, Mouse, NHP, In vitro
PK/PD
Experiment
In vivo , BA3021 has potent and durable antitumor activity in human cancer xenograft mouse models, including patient-derived xenograft models.
Toxicology
Species
NHP, Mouse, Human
Toxicology
Animal (cat.)
Human, Mouse, NHP, In vitro
Toxicology
Major finding
CRI-CCTG-0003/IND.240 an immunotherapy platform study in platinum-resistant high grade serous ovarian cancer (IPROC): Sub-studies A and B: Durvalumab (D) + mecbotamab vedotin (BA3011) or ozuriftamab vedotin (BA3021).. IPROC is an ongoing platform trial investigating novel immunotherapy combinations in platinum resistant high grade serous ovarian cancer. Here we report on the combination of durvalu…
Clinical
Data Tier / Score
A · 12
Clinical
Program phase
PHASE_2
Clinical
Clinical sync
2026년 7월 13일 (1일 전)