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검색으로 10,000+ 프로그램 중 최대 5개를 골라 PK/PD · 독성 · 임상을 나란히 비교합니다. · 다음 갱신 D-13 · 마지막 7월 13일

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항목
ADCPhase 3
Cyclin-Dependent Kinase 6 Inhibitor (Cyclin-Dependent Kinase 6 Inhibitor)
SWOG Cancer Research Network·HER2
ORR 24%
Overview
Program
Cyclin-Dependent Kinase 6 Inhibitor
Overview
Company
SWOG Cancer Research Network
Overview
Modality
ADC
Overview
Target
HER2
Overview
Indication
Anatomic Stage IV Breast Cancer AJCC v8; Metastatic HER2-Positive Breast Carcinoma
Overview
Phase
PHASE_3
Overview
Status
RECRUITING
MoA
Mechanism
target of rapamycin (mTOR) pathway
MoA
Biomarker
biomarker for high-grade cervical lesion identification
PK/PD
Species
Mouse
PK/PD
Animal (cat.)
Mouse, In vitro
PK/PD
Experiment
PK
Toxicology
Species
Mouse
Toxicology
Animal (cat.)
Mouse, In vitro
Toxicology
Major finding
Anti colorectal cancer activity and in silico studies of novel pyridine nortopsentin analog as cyclin dependent kinase 6 inhibitor.. Nortopsentins are a vital class of deep-sea sponge metabolites which can be used as leads for antitumor agents. Although their action has been studied in several diseases' contexts, their cytotoxic activity against colorectal carcinoma has not yet been fully investig…
Clinical
Primary efficacy
ORR 24%
Clinical
ORR
24%
Clinical
PFS
36
Clinical
OS
64.6
Clinical
Result source
ClinicalTrials.gov NCT04887831
Clinical
Data Tier / Score
A · 57
Clinical
Program phase
PHASE_3
Clinical
Clinical sync
2026년 7월 13일 (1일 전)