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항목
ADCPhase 3
Liposomal doxorubicin (Liposomal doxorubicin)
Palleos Healthcare GmbH·Breast Neoplasms
60%·t½ 3 h
Overview
Program
Liposomal doxorubicin
Overview
Company
Palleos Healthcare GmbH
Overview
Modality
ADC
Overview
Target
Breast Neoplasms
Overview
Indication
Lymphoproliferative Disorder; HHV-8
Overview
Phase
PHASE_3
Overview
Status
RECRUITING
MoA
Mechanism
, Clinical and Translational Science
MoA
Biomarker
biomarkers of liposomal doxorubicin-induced hypersensitivity in breast cancer: A pilot study
PK/PD
Half-life
3 h
PK/PD
Species
Mouse, Rat, Study objectives were safety, response, survival, and pharmacokinetics (PK).
PK/PD
Animal (cat.)
Mouse, Rat
PK/PD
Experiment
pharmacokinetic
Toxicology
Species
Mouse, Rat, Study objectives were safety, response, survival, and pharmacokinetics (PK).
Toxicology
Animal (cat.)
Mouse, Rat
Toxicology
Major finding
interstitial lung disease was excluded, and treatment resumed with steroid cover
Clinical
Primary efficacy
60%
Clinical
PFS
86.6
Clinical
OS
98.3
Clinical
Result source
ClinicalTrials.gov NCT00712582
Clinical
Data Tier / Score
A · 50
Clinical
Program phase
PHASE_3
Clinical
Clinical sync
2026년 7월 9일 (5일 전)