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항목
CGTPhase 2
MB-CART2019.1 (zamtocabtagene autoleucel, zamtocabtagene autoleucel (MB-CART2019.1))
Miltenyi Biomedicine GmbH·B-Cell Neoplasm
10 trials
Overview
Program
zamtocabtagene autoleucel (MB-CART2019.1)
Overview
Company
Miltenyi Biomedicine GmbH
Overview
Modality
CGT
Overview
Target
B-Cell Neoplasm
Overview
Indication
Refractory Diffuse Large B Cell Lymphoma (DLBCL); Relapsed Diffuse Large B Cell Lymphoma
Overview
Phase
PHASE_2
Overview
Status
RECRUITING
MoA
Biomarker
biomarker assessments
PK/PD
Animal (cat.)
Unknown
PK/PD
Experiment
No dose-limiting toxicity and no cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome of grade ≥3 were observed.
Toxicology
Animal (cat.)
Unknown
Toxicology
Major finding
Zamtocabtagene autoleucel in relapsed/refractory B-NHL: 5-year follow-up of a CD20/19 tandem CAR T-cell phase 1 trial.. Emerging long-term data indicate relapse rates of >50% after CD19-redirected chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL). To reduce selective pressure on the CD19 antigen, we conducted a first-in-human phas…
Toxicology
CRS
Reported
Clinical
Data Tier / Score
A · 21
Clinical
Program phase
PHASE_2
Clinical
Clinical sync
2026년 7월 13일 (1일 전)