Pegfilgrastim(Amgen)은 Ovarian Cancer 표적 ADC로, Cancer; Colon Cancer 영역에서 개발·상용화 중입니다. 작용기전: Pegfilgrastim products are colony-stimulating factors that act on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiat. Phase 3 후기 임상 단계입니다. 대표 임상 효능: ORR 35% (ClinicalTrials.gov NCT00856492). PK: t½ 80 days. 차별점: novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier.
Ovarian Cancer
Cancer; Colon Cancer
Recruiting
humanized mouse model established by transplant of CD34 + bone marrow cells from 9 unique adult organ donors
novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier
Pegfilgrastim products are colony-stimulating factors that act on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end cell functiona
apoptosis with histologic features mimicking grade 1 graft-versus-host disease (GVHD) in the absence of prior transplantation
PD-L1-high
downregulation of major histocompatibility complex II (HLA-DR) and the ability to suppress T-cell proliferation in vitro
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.
Pegfilgrastim(Amgen)은 Ovarian Cancer 표적 ADC로, Cancer; Colon Cancer 영역에서 개발·상용화 중입니다. 작용기전: Pegfilgrastim products are colony-stimulating factors that act on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiat. Phase 3 후기 임상 단계입니다. 대표 임상 효능: ORR 35% (ClinicalTrials.gov NCT00856492). PK: t½ 80 days. 차별점: novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier.
Ovarian Cancer
Cancer; Colon Cancer
Recruiting
humanized mouse model established by transplant of CD34 + bone marrow cells from 9 unique adult organ donors
novel orally bioavailable small molecule, has demonstrated radioprotective effects in rodent models earlier
Pegfilgrastim products are colony-stimulating factors that act on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end cell functiona
apoptosis with histologic features mimicking grade 1 graft-versus-host disease (GVHD) in the absence of prior transplantation
PD-L1-high
downregulation of major histocompatibility complex II (HLA-DR) and the ability to suppress T-cell proliferation in vitro
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.