EMD Serono
Temozolomide (TMZ)(EMD Serono)은 Advanced Solid Malignancies 표적 ADC로, Childhood Cancer; Childhood Solid Tumor 영역에서 개발·상용화 중입니다. 작용기전: targets were involved in multiple biological processes, cellular components, molecular functions, and signaling pathway. Phase 2에서 효능·안전성 신호를 검증 중입니다. 대표 임상 효능: ORR 40% (ClinicalTrials.gov NCT01390948). PK: t½ 5 h. 차별점: unique drug-disease intersection targets were obtained after merging the TMZ-disease and CoQ10-disease targets and five core t.
Advanced Solid Malignancies
Childhood Cancer; Childhood Solid Tumor
Recruiting
SN-38 for the treatment of glioblastoma: Engi
lipid nanoparticles, dendrimers, and micelles
unique drug-disease intersection targets were obtained after merging the TMZ-disease and CoQ10-disease targets and five core t
targets were involved in multiple biological processes, cellular components, molecular functions, and signaling pathway
immune-mediated clearance
apoptosis-related genes ( p53, p21, Bax, Bcl-2, Bcl-xL , and caspase-3 ) was analysed by reverse transcription-quantitative polym
biomarkers for nitrosative stress, and apoptosis using western blot analysis, flow cytometry and AnnexinV/PI
resistance mechanisms, constrains TMZ efficacy
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.
EMD Serono
Temozolomide (TMZ)(EMD Serono)은 Advanced Solid Malignancies 표적 ADC로, Childhood Cancer; Childhood Solid Tumor 영역에서 개발·상용화 중입니다. 작용기전: targets were involved in multiple biological processes, cellular components, molecular functions, and signaling pathway. Phase 2에서 효능·안전성 신호를 검증 중입니다. 대표 임상 효능: ORR 40% (ClinicalTrials.gov NCT01390948). PK: t½ 5 h. 차별점: unique drug-disease intersection targets were obtained after merging the TMZ-disease and CoQ10-disease targets and five core t.
Advanced Solid Malignancies
Childhood Cancer; Childhood Solid Tumor
Recruiting
SN-38 for the treatment of glioblastoma: Engi
lipid nanoparticles, dendrimers, and micelles
unique drug-disease intersection targets were obtained after merging the TMZ-disease and CoQ10-disease targets and five core t
targets were involved in multiple biological processes, cellular components, molecular functions, and signaling pathway
immune-mediated clearance
apoptosis-related genes ( p53, p21, Bax, Bcl-2, Bcl-xL , and caspase-3 ) was analysed by reverse transcription-quantitative polym
biomarkers for nitrosative stress, and apoptosis using western blot analysis, flow cytometry and AnnexinV/PI
resistance mechanisms, constrains TMZ efficacy
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.