Tucatinib(Pfizer)은 Metastatic Breast Cancer 표적 ADC로, Dynamic Tumor Resistance; Metastatic Colorectal Cancer 영역에서 개발·상용화 중입니다. 작용기전: Targeting these proteins using multitargeted therapeutic strategies may overcome resistance by disrupting key signalling pathway. Phase 3 후기 임상 단계입니다. 대표 임상 효능: ORR 51.4% (ClinicalTrials.gov NCT04539938). PK: t½ 11.9 h. 차별점: novel scaffolds in the lead phytochemicals when compared to FDA-approved drugs.
Metastatic Breast Cancer
Dynamic Tumor Resistance; Metastatic Colorectal Cancer
Recruiting
ADC) to evaluate treatment efficacy
deruxtecan and tucatinib
lentiviral transduction
novel scaffolds in the lead phytochemicals when compared to FDA-approved drugs
Targeting these proteins using multitargeted therapeutic strategies may overcome resistance by disrupting key signalling pathway
DNA damage and increase apoptosis
HER2-positive
resistance mechanisms
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.
Tucatinib(Pfizer)은 Metastatic Breast Cancer 표적 ADC로, Dynamic Tumor Resistance; Metastatic Colorectal Cancer 영역에서 개발·상용화 중입니다. 작용기전: Targeting these proteins using multitargeted therapeutic strategies may overcome resistance by disrupting key signalling pathway. Phase 3 후기 임상 단계입니다. 대표 임상 효능: ORR 51.4% (ClinicalTrials.gov NCT04539938). PK: t½ 11.9 h. 차별점: novel scaffolds in the lead phytochemicals when compared to FDA-approved drugs.
Metastatic Breast Cancer
Dynamic Tumor Resistance; Metastatic Colorectal Cancer
Recruiting
ADC) to evaluate treatment efficacy
deruxtecan and tucatinib
lentiviral transduction
novel scaffolds in the lead phytochemicals when compared to FDA-approved drugs
Targeting these proteins using multitargeted therapeutic strategies may overcome resistance by disrupting key signalling pathway
DNA damage and increase apoptosis
HER2-positive
resistance mechanisms
차트 로드 중…
임상시험이 많습니다. 임상시험 탭에서 Phase/Status 필터·검색을 사용하세요.
수집된 임상 필드(phase, status, endpoint 등) 기반 자동 요약입니다.